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RU‑1044 · AUTOP‑RU‑0143University Research Foundation
Non‑provisional · small entity
Non‑provisional · small entity
A bifunctional degrader scaffold selective for a hard‑to‑drug oncogenic mutation
S. Halvorsen, J. Ibarra, T. Nguyen, R. Adeyemi
Department of Medicinal Chemistry · University Cancer Research Institute · bioRxiv preprint · 09 Jun 2026
Department of Medicinal Chemistry · University Cancer Research Institute · bioRxiv preprint · 09 Jun 2026
Source disclosure. A bifunctional compound recruits a ubiquitin ligase to a mutant target protein through a targeting moiety that engages a structural feature unique to the disclosed variant. The compound degrades the mutant protein with high selectivity over the wild‑type form and shows efficacy in disease‑relevant models.
Patentability read. Reported approaches to this target rely on a binding handle absent from the disclosed variant. The selectivity element and the linker geometry are not disclosed in the retrieved art.
source linked
Inventors auto‑identified: 4
Federal grant linked
93PATLY
$4.60M$2.90M to $7.80M
Disclosure IDRU‑1044
PatentabilityStrong
Patent clock2.1 months left
Recommended filingNon‑provisional
TTO statusRouted ✓
●4 inventors identified · disclosure grounded to source
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